Endocrine Abstracts

Denosumab is a fully human MAB that inhibits bone resorption by neutralizing RANKL and was licensed in 2010 for the treatment of post-menopausal osteoporosis. It was first integrated in a northwest trust, under the care of the metabolic and bone disease department, as a second line treatment.Since 2012 denosumab has been used in the outpatient clinic under a shared care agreement with the greater Manchester medicines management group, this agreement ensu...

McCune–Albright syndrome and fibrous dysplasia are a rare sporadic skeletal disorder in which normal bone structures and marrow are replaced by a benign fibrous tissue. The disease can be limited to one or many bones and is more prevalent in females. One of the clinical consequences experienced by patients is severe bone pain for which bisphosphonates are an effective treatment.By the use of a nursing model for the treatment of the patient with this...

Zoledronic acid (5 mg) is used as an annual intravenous infusion for the treatment of post menopausal Osteoporosis, Paget's disease, Hypercalcaemia and more recently complex regional pain syndrome. Zoledronic acid is a potent anti-resorptive preparation used to slow bone breakdown, increase bone density and decrease the amount of Calcium released from the bones into the blood. Previously patients were reviewed in the outpatients clinic whereby bloods tests, Parathyroid hormone...

Osteoporosis is estimated to effect more than 3 million people in UK and secondary osteoporosis accounts for about 30% of women and 55% of men with vertebral fractures. There are many causes of secondary osteoporosis, such as endocrine, gastrointestinal disorders, steroid use, as well as immobility, obesity, bulimia and anorexia nervosa. We present a case of Osteoporosis secondary to anorexia nervosa.77 year”s old lady initially referred to bone clinic at the age of 46 wi...

Vitamin D deficiency has been estimated to affect one billion people world wide1. It is especially prevalent in Coeliac disease which is estimated to affect one in a 100 people. The intolerance to absorb gluten reduces not only the absorption of calcium, but can also further induce secondary hyperparathyroidism, infertility and a small increased risk of bowel carcinoma and osteoporosis.A joint nurse/dietetic Coeliac and Osteoporosis clinic was...